2023
Amiri M, Kiniry SJ, Possemato AP, Mahmood N, Basiri T, Dufour CR, Tabatabaei N, Deng Q, Bellucci MA, Harwalkar K, Stokes MP, Giguère V, Kaufman RJ, Yamanaka Y, Baranov PV, Tahmasebi S*, Sonenberg N*. Impact of eIF2α phosphorylation on the translational landscape of mouse embryonic stem cells. Cell Rep. 2023 Dec 28;43(1):113615. doi: 10.1016/j.celrep.2023.113615. Online ahead of print.
Cao Y, Liu H, Lu SS, Jones KA, Govind AP, Jeyifous O, Simmons CQ, Tabatabaei N, Green WN, Holder JL Jr, Tahmasebi S, George AL Jr, Dickinson BC. RNA-based translation activators for targeted gene upregulation. Nat Commun. 2023 Oct 26;14(1):6827. doi: 10.1038/s41467-023-42252-z.
2022
Toboz P, Amiri M, Tabatabaei N, Dufour CR, Kim SH, Fillebeen C, Ayemoba CE, Khoutorsky A, Nairz M, Shao L, Pajcini KV, Kim KW, Giguère V, Oliveira RL, Constante M, Santos MM, Morales CR, Pantopoulos K, Sonenberg N, Pinho S, Tahmasebi S*.The amino acid sensor GCN2 controls red blood cell clearance and iron metabolism through regulation of liver macrophages. Proc Natl Acad Sci U S A. 2022 Aug 30;119(35):e2121251119. doi: 10.1073/pnas.2121251119.
Farooq Z, Kusuma F, Burke P, Dufour CR, Lee D, Tabatabaei N, Toboz P, Radovani E, Greenblatt JF, Rehman J, Class J, Khoutorsky A, Fonseca BD, Richner JM, Mercier E, Bourque G, Giguère V, Subramaniam AR, Han J, Tahmasebi S*. The amino acid sensor GCN2 suppresses terminal oligopyrimidine (TOP) mRNA translation via La-related protein 1 (LARP1). J Biol Chem. 2022 Jul 19;298(9):102277. doi: 10.1016/j.jbc.2022.102277.
Tansley S, Uttam S, Ureña Guzmán A, Yaqubi M, Pacis A, Parisien M, Deamond H, Wong C, Rabau O, Brown N, Haglund L, Ouellet J, Santaguida C, Ribeiro-da-Silva A, Tahmasebi S, Prager-Khoutorsky M, Ragoussis J, Zhang J, Salter MW, Diatchenko L, Healy LM, Mogil JS, Khoutorsky A. Single-cell RNA sequencing reveals time- and sex-specific responses of mouse spinal cord microglia to peripheral nerve injury and links ApoE to chronic pain. Nat Commun. 2022 Feb 11;13(1):843. doi: 10.1038/s41467-022-28473-8.
2021
Roque PS, Hooshmandi M, Neagu-Lund L, Yin S, Yousefpour N, Sato H, Sato T, Nakadate Y, Kawakami A, Tahmasebi S, Ribeiro-da-Silva A, Gkogkas CG, Prager-Khoutorsky M, Schricker T, Wykes L, Khoutorsky A. Intranasal insulin rescues repeated anesthesia-induced deficits in synaptic plasticity and memory and prevents apoptosis in neonatal mice via mTORC1. Sci Rep. 2021 Jul 29;11(1):15490. doi: 10.1038/s41598-021-94849-3.
Hooshmandi M, Truong VT, Fields E, Thomas RE, Wong C, Sharma V, Gantois I, Soriano Roque P, Chalkiadaki K, Wu N, Chakraborty A, Tahmasebi S, Prager-Khoutorsky M, Sonenberg N, Suvrathan A, Watt AJ, Gkogkas CG, Khoutorsky A. 4E-BP2-dependent translation in cerebellar Purkinje cells controls spatial memory but not autism-like behaviors. Cell Rep. 2021 Apr 27;35(4):109036. doi:10.1016/j.celrep.2021.109036.
Sharma V, Sood R, Lou D, Hung TY, Lévesque M, Han Y, Levett JY, Wang P, Murthy S, Tansley S, Wang S, Siddiqui N, Tahmasebi S, Rosenblum K, Avoli M, Lacaille JC, Sonenberg N, Khoutorsky A. 4E-BP2-dependent translation in parvalbumin neurons controls epileptic seizure threshold. Proc Natl Acad Sci U S A. 2021 Apr 13;118(15):e2025522118. doi: 10.1073/pnas.2025522118.PMID: 33876772
2020
Tabatabaei N, Hou Sh, Kim K-W, Tahmasebi S*. Signaling pathways that control mRNA translation initiation in macrophages. Cell Signal. 2020 Jun 25;73:109700. doi: 10.1016/j.cellsig.2020.109700.
Pearl D, Katsumura S, Amiri M, Tabatabaei N, Zhang X, Vinette V, Pang X, Beug ST, Kim SH, Jones LM, Robichaud N, Ong SG, Jia JJ, Ali H, Tremblay ML, Jaramillo M, Alain T, Morita M, Sonenberg N, Tahmasebi S*. 4E-BP-Dependent Translational Control of Irf8 Mediates Adipose Tissue Macrophage Inflammatory Response. J Immunol. 2020 May 1;204(9):2392-2400. doi: 10.4049/jimmunol.1900538. Epub 2020 Mar 25.
Muendlein HI, Sarhan J, Liu BC, Connolly WM, Schworer SA, Smirnova I, Tang AY, Ilyukha V, Pietruska J, Tahmasebi S, Sonenberg N, Degterev A, Poltorak A. Constitutive Interferon Attenuates RIPK1/3-Mediated Cytokine Translation. Cell Rep. 2020 Jan 21;30(3):699-713.e4. doi: 10.1016/j.celrep.2019.12.073.
2019
SB, Lee WH, Shao NY, Ismail NI, Katwadi K, Lim MM, Kwek XY, Michel NA, Li J, Newson J, Tahmasebi S, Rehman J, Kodo K, Jang HR, Ong SG. Calpain Inhibition Restores Autophagy and Prevents Mitochondrial Fragmentation in a Human iPSC Model of Diabetic Endotheliopathy. Stem Cell Reports. 2019 Mar 5;12(3):597-610. doi: 10.1016/j.stemcr.2019.01.017. Epub 2019 Feb 21.
Tahmasebi S, Amiri M, Sonenberg N. Translational Control in Stem Cells. Frontiers in Genetics. 2019 Jan 15;9:709. doi: 10.3389/fgene.2018.00709. eCollection 2018. Review.
2018
Zakaria C, Sean P, Hoang HD, Leroux LP, Watson M, Workenhe ST, Hearnden J, Pearl D, Truong VT, Robichaud N, Yanagiya A, Tahmasebi S, Jafarnejad SM, Jia JJ, Pelin A, Diallo JS, Le Boeuf F, Bell JC, Mossman KL, Graber TE, Jaramillo M, Sonenberg N, Alain T. Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis. PLOS Pathogens. 2018 Aug 23;14(8):e1007264. doi: 10.1371/journal.ppat.1007264. eCollection 2018 Aug.
Tahmasebi S*, Khoutorsky A, Mathews MB, Sonenberg N*. Translation deregulation in human disease. Nat Rev Mol Cell Biol 2018 Jul 23. doi: 10.1038/s41580-018-0034-x. *Co-corresponding.
Tahmasebi S, Sonenberg N, Hershey JWB, Mathews MB. 2018 Protein Synthesis and Translational Control: A Historical Perspective.Cold Spring Harb Perspect Biol. Aug 6. pii: a035584. doi: 10.1101/cshperspect.a035584.
Before 2017
Tahmasebi S*, Jafarnejad SM*, Tam IS, Gonatopoulos-Pournatzis T, Matta-Camacho E, Tsukumo Y, Yanagiya A, Li W, Atlasi Y, Caron M, Braunschweig U, Pearl D, Khoutorsky A, Gkogkas CG, Nadon R, Bourque G, Yang XJ, Tian B, Stunnenberg HG, Yamanaka Y, Blencowe BJ, Giguère V, Sonenberg N. Control of embryonic stem cell self-renewal and differentiation via coordinated alternative splicing and translation of YY2. Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12360-12367. *co-first authors.
Khoutorsky A, Sorge RE, Prager-Khoutorsky M, Pawlowski SA, Longo G, Jafarnejad SM, Tahmasebi S, Martin LJ, Pitcher MH, Gkogkas CG, Sharif-Naeini R, Ribeiro-da-Silva A, Bourque CW, Cervero F, Mogil JS, Sonenberg N. eIF2α phosphorylation controls thermal nociception. Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11949-11954. Epub 2016 Oct 3.
Fonseca BD, Zakaria C, Jia JJ, Graber TE, Svitkin Y, Tahmasebi S, Healy D, Hoang HD, Jensen JM, Diao IT, Lussier A, Dajadian C, Padmanabhan N, Wang W, Matta-Camacho E, Hearnden J, Smith EM, Tsukumo Y, Yanagiya A, Morita M, Petroulakis E, Gonzalez JL, Hernandez G, Alain T, Damgaard CK. La-related protein 1 (LARP1) represses terminal oligopyrimidine (TOP) mRNA translation downstream of mTOR complex 1 (mTORC1). J Biol Chem. 2015 May 4. pii: jbc.M114.621730.
Tahmasebi S*, Ghorbani M*, Savage P, Gocevski G, Yang XJ. The SUMO conjugating enzyme Ubc9 is required for inducing and maintaining stem cell pluripotency. Stem Cells; 2014 Apr;32(4):1012-20. doi: 10.1002/stem.1600. *co-first authors.
Tahmasebi S, Alain T, Rajasekhar VK, Zhang JP, Prager-Khoutorsky M, Khoutorsky A, Dogan Y, Gkogkas CG, Petroulakis E, Sylvestre A, Ghorbani M, Assadian S, Yamanaka Y, Vinagolu Baur JR, Teodoro JG, Kim K, Yang XJ, and Sonenberg N. Multifaceted regulation of somatic cell reprogramming by mRNA translational control. Cell Stem Cell. 2014 May 1;14(5):606-16. doi: 10.1016/j.stem.2014.02.005. Epub 2014 Mar 13.
Tahmasebi S, Ghorbani M, Savage P, Yan K, Gocevski G, Xiao L, You L, Yang XJ. Sumoylation of Kruppel-like factor 4 inhibits pluripotency induction but promotes adipocyte differentiation. J Biol Chem. 2013 May 3;288(18):12791-804. doi: 10.1074/jbc.M113.465443. Epub 2013 Mar 20.
Ullah M, Pelletier N, Xiao L, Zhao SP, Wang K, Degerny C, Tahmasebi S, Cayrou C, Doyon Y, Goh SL, Champagne N, Côté J, Yang XJ. Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes. Mol Cell Biol. 2008 Nov;28(22):6828-43. Epub 2008 Sep 15.
Walkinshaw DR, Tahmasebi S, Bertos NR, Yang XJ, Histone deacetylases as transducers and targets of nuclear signaling. J Cell Biochem. 2008 Apr 18.
Kroos M, Pomponio RJ, van Vliet L, Palmer RE, Phipps M, Van der Helm R, Halley D, Reuser A; GAA Database Consortium Update of the Pompe disease mutation database with 107 sequence variants and a format for severity rating. Hum Mutat. 2008 Jun;29(6):E13-26.
Ghaffari SR, Sabokbar T, Tahmasebi S, Dastan J, Shorakae S, Moradi A, Tirgari F, Mohagheghi MA, Mosavi-Jarrahi A.Combining mammaglobin and carcinoembryonic mRNA markers for early detection of micrometastases from breast cancers–a molecular study of 59 patients. Asian Pac J Cancer Prev. 2006 Jul-Sep;7(3):396-8.
Yazdizadeh B, Jarrahi AM, Mortazavi H, Mohagheghi MA, Tahmasebi S, Nahvijo A. 2005 Time trends in the occurrence of major GI cancers in Iran. Asian Pac J Cancer Prev. Apr-Jun; 6(2):130-4.
Mosavi-Jarrahi A, Mohagheghi M, Yazdizadeh B, Kolahi AA, Tahmasebi S, Sharifi S. 2004 Analysis of smoking behaviour among Iranian population: a cohort and period analysis. Asian Pac J Cancer Prev. Jan-Mar; 5(1):66-9.